Posted 1:57 p.m. Thursday, Sept. 13, 2018
UWL researchers — experienced and emerging — are searching for answers to a global health threat: antibiotic resistance.
UWL researchers — experienced and emerging — are searching for answers to a global health threat: antibiotic resistance
Antibiotic resistant bacteria are a growing, deadly problem worldwide. At least 2 million people in the U.S. each year become infected with bacteria that are resistant to antibiotics and 23,000 of those don’t survive, according to the Centers for Disease Control and Prevention. Meanwhile, some estimates indicate more than 700,000 people globally die each year due to drug-resistant infections. Developing new antibiotics is a key part of combating the issue. Among those fighting the battle are UWL scientists — both long-term and emerging. Several UWL faculty formed the Mycophyte Discovery group. Over the last two decades, these professors — Aaron Monte, Chemistry; Marc Rott and William Schwan, Microbiology; Anne Galbraith, Jennifer Miskowski and Thomas Volk, Biology — have been learning about microorganisms that have the potential to cause dangerous infections in humans. They are developing new antibiotics and other anti-infectives from Native American herbal remedies and wild fungi. Alongside them are UWL student researchers, including some incoming, first-year students and sophomores in UWL’s Eagle Apprentice Program. “We’ve had a number of papers published that included undergraduate and graduate student authors,” says Schwan. “It’s been a big feather in the cap of these students to have contributed to peer-reviewed science.”Emerging scientists help make new discoveries
When UWL junior Lillian Schulte stepped into Professor Schwan’s lab as an Eagle Apprentice her first year at UWL, she admits feeling intimidated. Yet, she found working at the bench alongside passionate researchers inspiring. [caption id="attachment_52833" align="alignright" width="300"] From left, graduate student Allison Zank, Professor William Schwan and UWL junior Lillian Schulte. In addition to studying Staphylococcus aureus and its biofilm formation, Schwan also studies another kind of bacteria that is the No. 1 cause of urinary tract infections: Escherichia coli, among other topics.[/caption] “They really cared about what they were working on,” she says. “It was cool to be a part of that.” One of the biggest problems Schwan’s research team was working on — and continues to work on — is an antibiotic resistant bacteria called Staphylococcus aureus. Categorized as a “serious concern” by the CDC, this species of bacteria is a major problem in U.S. hospitals where it has become the leading cause of heart valve and blood stream infections, explains Schwan who has studied this bacteria since his days working at a Washington-based biotechnology company more than 20 years ago. Staphylococcus aureus starts as a single cell that can adhere to a surface such as a man-made device in the human body. The bacteria then multiply and create a thin film — a matrix of sugars, proteins, DNA and bacteria cells — that the body’s defenses can’t penetrate. Most antibiotics can’t get through it either. Schwan’s research aims to more fully understand this bacterial species and how it forms a biofilm. Answers from Schwan’s lab could be passed on to develop new drugs that could stop the film formation before it starts. Nine UWL students are working with Schwan on this and other projects this semester. Schwan says Eagle Apprentices, though new to scientific research at the university level, share qualities such as enthusiasm and strong academics. He watches them grow most— as scientists. “This is not like a lab course where nearly everything works,” Schwan explains. “There is a lot of failure and you have to pick yourself up by your bootstraps and solve what went wrong with your experiment. That is a good learning experience and it builds critical thinking in our students.”Over the years, Schulte’s role in the lab has grown increasingly complex, and she has moved from mentee to mentor. Last year she helped a new Eagle Apprentice get acquainted with the lab. This summer she earned a Dean’s Distinguished Fellowship, continuing to research Staphylococcus aureus and biofilms. “I’ve learned a lot here and I apply it in my courses,” she says. “Through that, I’ve gained a big confidence boost.”“I’ve learned a lot here and I apply it in my courses,” she says. “Through that, I’ve gained a big confidence boost.”